Industry is adapting to the increasing complexity and poor solubility and bioavailability of molecules in the pipeline. Poor solubility and low bioavailability have hindered the development pipeline ...
Bringing complex oral drugs to the clinic requires overcoming significant solubility, permeability, and bioavailability challenges. Many early-phase programs stall due to limited API supply, ...
Brooklyn, New York, May 23, 2022 (GLOBE NEWSWIRE) -- Reports and Insights has published a new report titled, “Pharmaceutical Solubility and Bioavailability Enhancement Market: Opportunity Analysis and ...
Drug discovery is a high-risk, high-cost endeavor, with over 90% of candidates failing in clinical development. A significant proportion of these failures stem from unresolved biopharmaceutic ...
Experts from Capsugel and Catalent discuss the rationale of using lipid0basd formulations to improve the oral bioavailability of poorly soluble drugs. Poor solubility remains an ongoing challenge in ...
Proteolysis-targeting chimeras (PROTACs), particularly those incorporating the von Hippel–Lindau (VHL) E3 ligase ligand, present significant physicochemical challenges due to their large molecular ...
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