Genome‑wide CRISPR screens in primary human T cells reveal human genes that promote or block HIV infection, uncovering potent ...

Scientists from Mass General Brigham and the Broad Institute of MIT and Harvard have used CRISPR screens to identify genetic modifications that influence T cell function and survival in cultures and ...

The immune system plays a crucial role in fighting tumours and metastases. Consequently, it is decisive to conduct cancer research in mouse models with an immune system that is as natural as possible ...

This figure shows the structure of PTGES3. The research team made the association after creating a fluorescent tag that tracks androgen receptor levels in real time. The androgen receptor is a hormone ...

A team of CiRA researchers has uncovered the crucial role of EIF3D—a protein translational regulator—in primed pluripotency. The research is published in the journal Science Advances. According to the ...

“While recent single-cell multiomics studies and CRISPR screens in murine NK cells have expanded our understanding, actionable genomic targets in primary human NK cells have remained largely ...

Fred Hutch researchers invent a CRISPR screening method to understand RNA-binding proteins often mutated in cancer and other diseases In biology’s standard tale of two acids — deoxyribonucleic (DNA) ...

While hundreds of different lipids have been identified in human blood, many of them remain functionally uncharacterized, including a class of lipids called long-chain acylcarnitines (LCACs). The use ...

Industry poised for growth, driven by advancements in precision drug discovery, rising gene therapy investments, and ...