Antisera were raised to the 210,000-dalton and the 49,000-dalton proteins of a fraction enriched in intermediate (10 nm) filaments from human brain. Proteins of the filament preparation were separated ...

Just as the skeleton and muscles move the human body and hold its shape, the cells of the body are stabilized and moved by a cellular skeleton. This cellular skeleton is a dynamic structure, ...

This is a preview. Log in through your library . Abstract The coding region of the hamster desmin gene was fused to the 5′ flanking sequences of the hamster vimentin gene and introduced into the germ ...

Neurofilament light (NfL) is a 68 kDa cytoskeletal intermediate filament protein highly expressed in neuronal axons. It is associated with the 125 kDa Neurofilament medium (NfM) and the 200 kDa ...

Glial Fibrillary Acidic Protein (GFAP) is a class-III intermediate filament that is mostly produced in astrocytic glial cells in the central nervous system. Astrocytes have important functions in ...

The symptoms of neurodegenerative diseases like Alzheimer’s, frontotemporal dementia, and chronic traumatic encephalopathy (CTE) are different, but they have one feature in common: the presence of ...

Credit: Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2418624122 Scientists have uncovered new details about cellular filaments that play a critical role in wound healing, ...

Structures called desmosomes connect cells to each other and transfer mechanical stress. They are especially important in tissues under continual mechanical stress, such as heart muscle (pictured).

How does skin hold you in? How do heart cells beat together? Researchers at the University of California, Davis, Department of Biomedical Engineering, are exploring how structures called desmosomes, ...