Processive DNA polymerases that replicate chromosomes interact with a ring-shaped clamp that encircles DNA and slides along the duplex. All sliding clamps (Escherichia coli β-clamp, T4 bacteriophage ...
Mismatched nucleotides arise from polymerase misincorporation errors, recombination between heteroallelic parents and chemical or physical DNA damage 1. Highly conserved MutS (MSH) and MutL (MLH/PMS) ...
An elusive step in the process of human DNA replication has been observed for the first time, report scientists at Penn State University. The scientists say they’ve discovered how a key step in human ...
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