Retroviral integration is infrequent compared with the number of viral complementary DNA reverse transcripts found in infected cells 1. The possibility that integration chemistry might account for ...

The re-transcribed DNA is then integrated into the genome of the host cell (Figure 2). This process requires the absence of the nuclear membrane and thus is restricted to the M-phase of proliferating ...

Graft-versus-host disease (GvHD) is a severe complication in the context of allogeneic stem cell transplantation and adoptive immunotherapy. The transfer of a suicide gene into donor T-lymphocytes ...

Some HIV-infected – and untreated – children do not develop AIDS. A new study shows that they control the virus in a different way from the few infected adults who remain disease-free, and sheds light ...

Retroviruses such as HIV must insert their viral DNA into host-cell DNA. A new study reveals details about the viral DNA's search for an insertion point. The findings could help improve treatments for ...

Phase I trial and pharmacokinetic study of pyrazoloacridine in children and young adults with refractory cancers. Normal bone marrow cells have little or no expression of the MDR p-glycoprotein ...

HIV anti-retroviral therapy is considered a treatment and not a cure because patients usually carry a reservoir of HIV-infected cells that can re-emerge if treatment stops. These reservoirs have long ...

Endogenous retroviral elements (ERVs)—the ancient viral DNA sequences that lurk in our genome—have lost the ability to produce viral particles, but they can still cause mischief. For example, they can ...

Bone marrow involvement in Hodgkin's disease: an analysis of 135 consecutive cases. German Hodgkin's Lymphoma Study Group. All of the patients tolerated the treatment well and none of the theoretic ...

Drugs developed to treat AIDS and HIV could offer hope to patients diagnosed with the most common form of primary brain tumor. It should come as no surprise that as we age, physical activity becomes ...

Since the recombinant viral genomes are devoid of any viral genes (which are also not expressed by the infected target cell), the recombinant viral vectors can only infect a cell and are replication ...