The Notch signaling pathway is a critical component of cardiovascular formation and morphogenesis in both development and disease. It is required for the selection of endothelial tip and stalk cells during …

Mar 24, 2022 · We summarized both classical and cutting-edge findings of NOTCH signaling in this review, illustrating the history, architecture, regulatory mechanism, physiology, and pathology of …

Notch signaling. Following ligand binding, signaling is initiated when endocytosis of ligand–receptor complexes induces unfolding of a juxtamembrane negative control region (NRR) unique to Notch …

Apr 29, 2025 · The Notch signaling pathway is a crucial communication system influencing cell differentiation, proliferation, and apoptosis. Its significance extends from embryonic development to …

The Notch signaling pathway is a communication system between cells that regulates various cellular processes, including cell proliferation, differentiation, and cell fate determination. It is also crucial for …

Jan 9, 2026 · Notch signaling is an evolutionarily conserved pathway in multicellular organisms that regulates cell-fate determination during development and maintains adult tissue homeostasis.

Feb 20, 2025 · As a highly conserved intercellular signaling pathway, “Notch” was observed in a variety of eukaryotic organisms. It transmits signals through interactions between neighboring cells and can …

Mar 10, 2025 · This Review discusses how different modes of Notch signalling can have different functional outcomes, and how their dysregulation is associated with cancer states.

A hallmark of Notch signaling that sets it apart from other conserved signaling pathways is its mechanism of signal transduction. Notch signaling relies on the ability of a ligand to bring about …

The Notch signaling pathway plays a critical role in regulating cell communication. This pathway is essential in multiple biological processes including cell fate decisions, differentiation, and the …